A new bis-labdanic diterpene from the rhizomes of Alpinia pahangensis

Sivasothy Y 1 , Ibrahim H 2 , Paliany AS 2 , Alias SA 2 , Md Nor NR 3 , Awang K 1

Affiliations 

  • 1 Department of Chemistry, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia
  • 2 Institute of Biological Sciences, Faculty of Science, University Malaya, Kuala Lumpur, Malaysia
  • 3 Chemistry Department, Center of Foundation Studies, International Islamic University Malaysia, Selangor, Malaysia
Planta Med, 2013 Dec;79(18):1775-80.
PMID: 24356874 DOI: 10.1055/s-0033-1351075

Abstract

The rhizomes of Alpinia pahangensis yielded a new bis-labdanic diterpene for which the name pahangensin C (1) was proposed along with twelve known analogues (2-13). The structure of 1 was elucidated via spectroscopic methods including 1D and 2D NMR techniques and LCMS-IT-TOF analysis. Compounds 2 and 12 were isolated for the first time from the genus Alpinia. This is the second occurrence of compounds 2 and 12 in the Zingiberaceae family. Selected analogues exhibited moderate to strong inhibitory activity against Staphylococcus aureus and Bacillus cereus.

* Title and MeSH Headings from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

MeSH terms
Similar publications